منابع مشابه
RNA in human sperm.
We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa. This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in preparation for their delivery to the egg. The diversity of these transcripts is vast, including several anti-sense molecules resembling known regulatory micro-RNAs. The field is...
متن کاملA Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference.
Short interfering RNAs (siRNAs) are a class of regulatory effectors that enforce gene silencing through formation of RNA duplexes. Although progress has been made in identifying the capabilities of siRNAs in silencing foreign RNA and transposable elements, siRNA functions in endogenous gene regulation have remained mysterious. In certain organisms, siRNA biosynthesis involves novel enzymes that...
متن کاملIncreased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia
Male infertility is a worldwide medical problem. Asthenozoospermia is a common cause of infertility. Epigenetic modifications of DNA and histones have been shown to influence human infertility, but no research has explored whether N(6)-methyladenosine (m(6)A) level in RNA is associated with asthenozoospermia. Here, we collected a total of 52 semen samples, including 20 asthenozoospermia patient...
متن کاملCryobanking of human sperm.
The primary use of frozen semen has been for the treatment of male infertility, in which case a 'donor's' semen may be used for insemination independently of time and place. An increase in demand for semen by infertile couples, who represent about 30 per cent of all marriages in the United States, was a contributing factor to the rapid growth of commercial semen banking. Another factor was the ...
متن کاملRNA IN SPERM: TOWARDS AN IDENTIFICATION OF RNAs TRANSMITTED FROM SPERM TO ZYGOTE ON FERTILIZATION
INTRODUCTION It is widely recognized that all that fathers essentially contribute to the next generation is half of their genome, and mature sperm cells are transcriptionally and translationally inactive. However, an increasing number of reports have shown that RNAs were present in human sperm detected by using RT-PCR, differential display, in situ hybridization and microarrays [1]. One study s...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2005
ISSN: 1008-682X,1745-7262
DOI: 10.1111/j.1745-7262.2005.00048.x